Cell encapsulation is a bioengineering technology to protect cells from the host’s immune system to facilitate transplantation therapies and overcome the existing problem of graft rejection in tissue engineering applications and reduce the need for immunosuppressive drugs after an organ transplant to control side effects. Cell encapsulation is a method used to treat a wide range of neurological diseases. It has been useful in live mammalian & bacterial cells, immobilization of drugs, and other biopharmaceutics molecules. Cell encapsulation can protect encapsulated contents to prevent the degradation of the product due to external factors of the environment and has been proven useful to provide material structuration, therapeutic product protection, and targeted delivery & controlled release of the encapsulated biotherapeutics.
The global live cell encapsulation market size was valued at USD 263 million in 2019 and projected to reach USD 350 million by 2027, growing at a CAGR of 3.6% during the forecast period, 2020-2027. The major factors are the growing demand for cell encapsulation for diseases treatment with the increasing adoption of novel drug delivery systems. Additionally, the increasing utilization of microencapsulated drugs for the treatment of numerous diseases such as Cancer, Diabetes, Parkinson’s disease, Lysosomal storage disease, hemophilia, Gastrointestinal disorders, Pulmonary diseases, Hormone therapy, Hypertension, and Periodontitis, will spur the global live cell encapsulation industry in the future periods. Furthermore, the growing public-private funding for cell encapsulation activities and rise in the adoption of alternative therapies is expected to witness remarkable growth of the live-cell encapsulation market. The increasing clinical usage of live cell encapsulation in pharmacology, such as drug delivery and regenerative medicines to heal and transplant damaged tissue or organ, is expected to propel cell encapsulation demand over the coming years.
Moreover, the upsurge in demand for cell encapsulation in the pharmaceutical, agrochemical, and food industries positively impacts the market for live-cell encapsulation in the healthcare industry. Furthermore, the rapid expansion customer base, rise in the extensive R&D activities at the academic and industrial level, and increasing scope of encapsulation technology are fueling the demand for cell encapsulation in the healthcare market. The growing applications of cell encapsulation in drug delivery, organ transplantation, and probiotics will bolster the growth of the global cell encapsulation market share. Additionally, the growing clinical role and increasing healthcare demands in the developing world propelling the growth of the cell encapsulation market across the globe.
Cell encapsulation is used in food applications, including stabilizing food ingredients and improved delivery of bioactive molecules into food. Due to the advanced improvement in cell-based delivery systems, it has gained the attention of researchers and attracted various biotechnological companies to the layout to develop from micro to macro encapsulation devices. Cell encapsulation is most widely used in stem cell treatment and cell therapy research. Moreover, it has improved enormously, and certain advantages over other alternative systems such as repetitive drug administration prevention have triggered technology in several therapeutic applications. The Encapsulation technology applications are not limited to the pharmaceutical, agriculture, enzyme, and food industry. They are used widely in the cosmetics & fragrance industry to optimize new cosmetic active ingredients, which will trigger the market’s growth. However, the lack of unskilled professionals and high instrument manufacturing costs can restrain the market.
Based on the manufacturing techniques, the global live cell encapsulation market is categorized into Electrostatic Dripping, Simple Dripping, Liquid Jet Break Up, Coaxial Airflow, Vibrating Jet, Jet Cutting, and Rotating Disk Atomization. The Electrostatic Dripping segment is estimated to witness the highest growth over the analysis timeframe. It is attributed to the procedural benefits such as retention of cell viability, potency, and uniform size distribution.
The Coaxial Airflow will grow significantly due to the rising encapsulated products adoption and the rise in the utilization of cell encapsulation technology.
Based on the polymer type, the global live cell encapsulation market is categorized into alginate, HEMA-MMA, chitosan, siliceous encapsulates, cellulose sulfate, PAN-PVC, and other polymers. The alginate segment is held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to the factors such as high permeability & high-quality purification and highly preferred in oil encapsulation because of its high gelling capacity and low toxicity.
The HEMA-MMA (Hydroxyethyl methacrylate-methyl methacrylate) segment is poised to witness significant growth over the forecast period due to its optimum physical properties and purity effect.
The global live cell encapsulation market is classified into drug delivery, regenerative medicine, cell transplantation, probiotics, and Research. The drug delivery is expected to be the highest revenue share for the cell encapsulation market during the forecast period. The segment’s growth is primarily attributed to the rising incidence of chronic illness and rising research activities on live-cell encapsulation.
CELL transplantation will witness a lucrative growth rate in the estimated period due to rising clinical research activities and the rising prevalence of neurogenerative diseases.
The global live cell encapsulation market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa. North America is estimated to project considerable growth over 2020-2026. It is due to increasing research activities in live-cell encapsulation, leading industry players offering innovative products, and increasing healthcare expenditure.
The Asia Pacific will produce a prominent share of the live-cell encapsulation market by 2027. Due to the rise in clinical data about the efficacy of cell encapsulation techniques, they are continually improving the healthcare framework in the region and mounting health care expenditures in emerging countries such as India and China.
Companies such as AltucellInc, BioTime Inc., BÜCHI Labortechnik AG, Backtrace Holdings Ltd, Beta-O2 Technologies Inc, Viacyte Inc., Living Cell Technologies Ltd, Sigilon Therapeutics Inc, Evonik Industries, Sernova Corporation, Neurotech Pharmaceuticals, Gloriana Therapeutics, Kadimastem, and Defymed are the key players in the global live cell encapsulation market.
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Global Live Cell Encapsulation Market
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