High-Resolution Melt analysis is a rapid, inexpensive sequence screening method. It is a powerful technique in molecular biology that is used to identify variations in nucleic acid sequences. HRM is used for the detection of mutations, polymorphisms, and epigenetic differences in double-stranded DNA samples. High-Resolution Melting (HRM) analysis is a quantitative analysis method based on detecting minor differences in PCR melting curves and can be considered the next-generation application of amplicon melting analysis.
The global high-resolution melting analysis market is expected to gain spurring CAGR in the forecast period from 2020-2027. The major factors are, day by day, growing demand for HRM analysis due to the rising prevalence of infectious diseases and genetic disorders. Additionally, the increasing benefits of HRM analysis technology such as significant accuracy, high efficacy, and short cycle times will spur the global high-resolution melting analysis industry in the future periods. Furthermore, the growing public-private funding in the genomics sector and the rising development of next-generation technology are expected to witness the remarkable growth of high-resolution melting analysis. The increasing demand for personalized medicine and rising development in the field of next-generation sequencing and big analytics data are expected to propel the demand for high-resolution melting analysis over the coming years.
Moreover, the increasing prevalence of chronic illness and the rising number of genotyping-based research and development projects positively impact the high-resolution melting analysis industry. Furthermore, the rapidly expanding customer base, the rise in the extensive R&D activities at the academic and industrial level, and the increasing scope of biomedical applications fuel the high-resolution melting analysis market demand. The growing population and increasing healthcare demands in the developing world propelling the growth of the high-resolution melting analysis market across the globe.
HRM analysis is an alternative to sequencing screening of new gene variants. HRM has several benefits over genotyping technologies such as simple & fast workflow, low sample & reagent consumption with little waste, fast optimization, no additional instrumentation is required after PCR amplification, and the prevention of sample contamination post-PCR. Because of the advantages of large market size, low market concentration, and gradual maturity of technology applications, HRM analysis technologies have attracted various enterprises to the layout. In addition, government funds & grants for developing novel therapies and extensive research & development in epigenetics drive the market. However, restrictions are often challenging to achieve. Also, the rising adoption of alternative technologies can hinder the growth of the market.
The global high-resolution melting analysis market is segregated into instruments, reagents & consumables, specialized PCR reagents, intercalating dyes, and software & services based on the product and service. The reagents & consumables segment is estimated to witness the highest growth over the analysis timeframe due to rising research on genetic disorders, cancer & HIV, low cost, and rapid expansion in customer base.
The instruments will grow significantly due to the rising HRM analysis instruments adoption and increasing HRM analysis applications, including identifying candidate predisposition genes, mutation discovery, & HLA, and continuously growing clinical industry coupled with increasing utilization.
Based on application, the global high-resolution melting analysis market is classified into SNP genotyping, mutation discovery, species identification, pathogen identification, epigenetics, and other applications. The SNP genotyping is expected to be the highest revenue share for high-resolution melting analysis at the forecast period. The segment’s growth primarily affects the growing consumption in biomedical applications, cost-effectiveness in mapping, and the ability to track disease genes’ inheritance within families.
The mutation discovery will witness a lucrative growth rate in the estimated period due to rising cancer prevalence and increasing demand for crop improvement.
Based on the end-user, the global high-resolution melting analysis market is segmented into pharmaceutical & biotechnology companies, research laboratories & academic institutes, hospitals & diagnostic centers, and other end users. The research laboratories & educational institutes segment will dominate the global high-resolution melting analysis market by 2027 just because of the increment in the number of research laboratories & academic institutes using HRM analysis technology, increasing demand for fast and powerful genotype analysis of larger samples for massive scale genotyping projects, and government focus on broader healthcare policies.
The hospitals & diagnostic centers accounted for the largest share of the high-resolution melting analysis market in 2019 because of the increasing use of HRM analysis in clinical diagnosis, rising demand for cancer detection, and increasing prevalence of genetic diseases.
By geography, the global high-resolution melting analysis market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa. North America is estimated to reach considerable growth over 2020-2026. It is due to advents in technology, leading industry players offering innovative products, and increasing healthcare expenditure.
The Asia Pacific will capture a significant share of the high-resolution melting analysis market by 2027. Because of the rising investment in R&D, they are continually improving healthcare infrastructure in the region and mounting health care expenditures in developing countries such as India and China.
Thermo Fisher Scientific Inc., QIAGEN N.V., Illumina Inc, F. Hofmann-La Roche Ltd, Agilent Technologies Inc, Bio-Rad Laboratories, Meridian Bioscience Inc, Azura Genomics, Biomérieux S.A., Canon Biomedical, and Premier Biosoft are the key players in the global high-resolution melting analysis market.
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