Hydrophobic Interaction Chromatography is a strong analytical technique used to separate proteins from one another. It involves hydrophobic groups such as phenyl, octyl, or butyl attached to the stationary column. HIC is a liquid chromatography used to purify and separate biomolecules by their hydrophobic interactions. HIC is a preferred technology for the separation of Protein compared to the other protein separation chromatography as it employs a less denaturing environment, maintains high biological activity, and less structural damage than others. HIC offers superior selectivity for removing aggregated species and undesirable misfolded or variant forms of a protein.
The global hydrophobic interaction chromatography market is expected to gain spurring CAGR in the forecast period from 2020-2027. The significant factors are the growing demand for monoclonal antibodies for the disease diagnosis and treatment of infectious diseases such as cancer. Additionally, the increasing utilization of hydrophobic interaction chromatography in the pharmaceuticals and biotechnology, food, and cosmetics industries to purify Protein and other biomolecules will spur the global hydrophobic interaction chromatography industry in the future periods. Furthermore, the growing public-private funding for protein purification techniques and increasing R&D investments are expected to witness remarkable growth of hydrophobic interaction chromatography. The expanding usage of hydrophobic interaction chromatography for purification of monoclonal antibodies for in-vitro diagnostics use and clinical studies of passive immunotherapy of HIV is expected to propel the demand for hydrophobic interaction chromatography over the coming years.
Moreover, the upsurge in demand for hydrophobic interaction chromatography to study drug-protein interaction and the rising demand for drug discovery& protein therapeutics positively impact the market for the hydrophobic interaction chromatography industry. Furthermore, the rapidly expanding customer demand base, rise in the extensive R&D activities at the academic and industrial level, and increasing range of biomedical applications are making the demand for hydrophobic interaction chromatography in the healthcare market. The growing usage of hydrophobic interaction chromatography in the removal of product-related impurities and contamination will bolster the growth of global hydrophobic interaction chromatography market share. Additionally, the ever-increasing geriatric population and growing healthcare demands in the developing world propelling the development of the hydrophobic interaction chromatography market across the globe.
Hydrophobic interaction chromatography (HIC) is widely used in isolating protein complexes and studying protein folding and unfolding. HIC has several advantages when coupled with ion-exchange chromatography, such as purification of recombinant HIV reverse transcriptase and mammalian transcription factor. HIC is also widely used in research laboratories. Because of the advantages of large market size, low market concentration, and gradual maturity of technology applications, HIC technology has attracted various enterprises to the layout. HIC technology has some benefits, such as loading large sample volumes and samples eluted with low salt. It reduces ionic strength will create high revenue in the healthcare industry. However, restrictions are often challenging to achieve. Also, the lack of trained professionals& qualified researchers and increasing use of alternative chromatography such as ion exchange and affinity chromatography may hamper the growth of the HIC market. Moreover, a hydrophobic interaction chromatography resin effectively used in separation techniques in the pharmaceuticals industry, food and beverages industry, water and environmental analysis, and diagnostics.
The global hydrophobic interaction chromatography market is segregated into resins, columns, buffers, other products, and services based on the product and services. The HIC resins segment is estimated to witness the highest growth over the analysis timeframe due to the rising demand for HIC resins to purify Protein, polypeptide, enzyme, and nucleic acid and increase use in water and environment analysis.
The column segment will grow significantly during the forecast period due to increased detection sensitivity, high efficiency & flow rate, and faster separation speed.
The global hydrophobic interaction chromatography market is categorized into monoclonal antibodies, vaccines, and other samples based on the model. The monoclonal antibodies segment held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to the rising demand for cancer diagnosis and treatment and increasing applications in autoimmune disorders and infectious diseases.
The vaccines segment is poised to witness significant growth over the forecast period due to rising demand for maximum purity in vaccines downstream processing and the increasing need to prevent and treat cancer and infectious disorders.
Based on the end-user, the global hydrophobic interaction chromatography market is segmented into pharmaceutical & biopharmaceutical companies, research & academic institutes, and CROs & CMOS. The pharmaceuticals and biotechnology companies segment will dominate the global hydrophobic interaction chromatography market by 2027. Due to the rising research and development funding by biopharmaceutical companies, increasing demand for therapeutic antibodies, and increasing use of HIC in the clinical trial setting.
The CROs and CMOs accounted for the largest share of the hydrophobic interaction chromatography market in 2019 on account of the increasing demand for purification of Protein and other biomolecules and rising research in the field proteomics.
By geography, the global hydrophobic interaction chromatography market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa. North America is estimated to projected considerable growth over 2020-2027. Due to the high demand for protein biologics, the adoption of automated purification technology, the presence of leading industry players offering innovative products, and increasing healthcare expenditure.
The Asia Pacific will capture a significant share of the hydrophobic interaction chromatography market by 2027. Due to the advents in technology, we are continually improving health care infrastructure in the region and mounting health care expenditures in developing countries such as India and China.
Companies such as Thermo Fisher Scientific, Waters Corporation, Sartorius AG, GE Healthcare, Bio-Rad Laboratories, Geno Technology, Tosoh Corporation, and Sepax Technologies are the key players in the global hydrophobic interaction chromatography market.
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