Immunoprecipitation is the isolation of an antigen using a specific antibody coupled to a sedimentable matrix. Immunoprecipitation is one of the most frequently used methods for isolating proteins and other biomolecules from cell or tissue lysates for upcoming detection by western blotting and other assay techniques. It is a powerful technique to concentrate and isolate a particular protein from a sample containing many thousands of different proteins. This method is used to study protein-protein interaction and isolate the protein of interest from complex samples such as cell lysates, serum, and tissue homogenates. It is used to measure the molecular weight of the given protein and determines the post-translational modification.
The global Immunoprecipitation market size was valued at USD 705.0 million in 2019 and projected to grow at a CAGR of 6.3% during the forecast period, 2020-2027. The major factors are the growing demand for precipitation is rising demand for antigen detection & purification associated with autoimmune disorders. Additionally, the increasing utilization of immunoprecipitation in life science research and modern cell biology will spur the global Immunoprecipitation industry in the future periods. Furthermore, the growing public-private funding for immunoprecipitation activities and increasing R&D investments are expected to witness remarkable growth of the immunoprecipitation market. The increasing use of immunoprecipitation in pharma, biotech, and academic labs for protein purification and expression is expected to propel the demand for immunoprecipitation over the coming years.
Moreover, the upsurge in demand for immunoprecipitation for a wide range of applications such as clone selection for recombinant protein expression of biomarker candidate verification in body fluids positively impacts the market for precipitation in the healthcare industry. Furthermore, the expanding customer base, rise in the extensive R&D activities at the academic and industrial level, and increasing innovation in cellular and genetic therapies fuel the demand for the immunoprecipitation market. Researchers routinely use immunoprecipitation to isolate proteins and prepare a small number of protein samples for analysis by western blot, ELISA, and other assays will bolster the growth of global precipitation market share. Additionally, the rising geriatric population and increasing healthcare demands in the developing world propelling the growth of the immunoprecipitation market across the globe.
Immunoprecipitation technology is used for the isolation of protein and biomolecules. The immunoprecipitation technology focuses on detecting the antigens through antigen-antibody interaction to understand disease mechanisms and the development of drugs targeting these diseases. Due to the advantages of large market size, low market concentration, and gradual maturity of technology applications, immunoprecipitation technologies have attracted various enterprises to the layout. Moreover, the Pharmaceuticals & biotechnology industries are widely using immunoassays in many important areas of pharmaceutical analysis such as therapeutic drug monitoring, diagnosis of diseases, clinical pharmacokinetics, and bioequivalence studies in drug discovery. However, the presence of alternative technologies for protein purification will be a restraint to the therapies.
Recently, the outbreak of COVID-19 has vigorously affected the healthcare system of developed and developing countries globally. The growing nervousness regarding the shortage of essential medical life-saving devices and other necessary medical supplies to prevent the spread of this virus and provide optimum care to the infected also widens. Additionally, the manufacturing process’s surge for a wide range of test kits and immunoassays will enhance the demand for immunoprecipitation in the healthcare industry.
Based on the product, the global immunoprecipitation market is segregated into kits, reagents, and accessories. The kits segment is estimated to witness the highest growth over the analysis timeframe due to the rise in adoption of immunoprecipitation products, rising demand for immunoprecipitation assays to isolate & purify antigens, and the requirement of a repetitive purchase of kits in research institutes. The reagents will grow significantly due to the repetitive use of antibodies, buffers, and beads in research institutes and industries. Additionally, agarose beads are widely used for the purification of protein by researchers.
Based on the type, the global immunoprecipitation market is categorized into Individual IP, Co-IP, ChIP (chromatin immunoprecipitation), and IP (Ribonucleic Acid Immunoprecipitation).
The individual protein immunoprecipitation segment is held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to its wide adaptation to improve the quality of a protein population before Western Blotting, increase use in the study of protein-protein interaction, and calculate an antigen’s relative quantity.
The Chromatin IP segment is poised to witness significant growth over the forecast period due to its ability to analyze gene targets and multiple antibodies simultaneously and provides accurate and rapid analysis without any pipetting risks.
Based on the end-user, the global immunoprecipitation market is segmented into pharmaceutical and biotechnology companies, academic & research institutes, and contract research organizations.
The academic & research institutes segment will dominate the global immunoprecipitation market by 2027. Due to the rising research activities in molecular biology and genomics, economic expansion, and government focus on broader healthcare policies.
The CROs accounted for the highest share of the immunoprecipitation market in 2019 on rising drug discovery & development activities and rising needs of outsourcing research activities and services by the large biopharmaceutical industries.
The global immunoprecipitation market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa.
North America is to project considerable growth over 2020-2026. It is due to the advent in technology, the presence of leading industry players offering innovative products, and increasing research in proteomics &genomics.
The Asia Pacific will gain a prominent share of the immunoprecipitation market by 2027. Due to the increasing biotechnology research, we are continually expanding healthcare infrastructure in the region and mounting health care frameworks in emerging countries such as India and China.
Companies such as Thermo Fisher Scientific, Abbkine Scientific Co. Ltd., Abcam plc, Bio-Rad Laboratories, BioLegend, Cell Signaling Technology Inc., Geno Technology Inc., GenScript, Biotech Corporation, Merck KGaA, Rockland Immunochemicals Inc., and Takara Bio Inc are the key players in the global immunoprecipitation market.
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Global Immunoprecipitation Market
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