Toxicology is a multidisciplinary field of science that helps to study adverse effects that occur in living organisms and the environment due to chemicals, substances, or situations. It involves observing and reporting symptoms that arise following exposure to toxic substances. It includes detecting, identifying, and quantifying hazards ensuing from human exposure to chemicals, public health aspects of toxic agents in the environment, and testing novel pharmaceutical products.
The In-vivo toxicology market size was valued at USD 4.83 billion in 2019 and projected to reach USD 7.32 billion by 2027, growing at a CAGR of 5.30% during the forecast period, 2020-2027. The significant factors are the growing demand for toxicology testing during drug development at an early stage and increasing R&D investments. Additionally, the ever-increasing advances in animal models and compulsory animal testing regulations will spur the in-vivo toxicology industry in the future periods. Furthermore, the growing public-private funding for pharmaceutical research activities and rising concerns for drug safety are expected to witness remarkable growth of in-vivo toxicology. The increasing demand for novel therapeutics and the rising number of clinical trials are expected to propel the demand for in-vivo toxicology over the coming years.
Moreover, the growth in demand for personalized medicine and strict government standards towards drug safety positively impacts the market for in-vivo toxicology in the healthcare industry. Furthermore, the rapidly expanding demand for new drugs, rise in the extensive R&D activities at the academic and industrial level, and increasing extent of biomedical applications are fueling the need for the in-vivo toxicology market. The growing applications of in-vivo toxicology in oncology research and the development of novel vaccines will bolster the growth of the global in-vivo toxicology market share. Additionally, the ever-increasing geriatric population and growing healthcare demands in the developing world propelling the development of the in-vivo toxicology market across the globe.
Toxicology screening is vital for the development of drugs. Pharmaceutical industries are rapidly adopting animal models to predict human toxicity. Animal models are good predictors of drug safety in humans as animal tests can genuinely identify a safe chemical as toxic and help find potentially beneficial drugs for human use. Also, the cost of animal models in comparison to in-vitro toxicology is low and consumes less time. In addition, animal models are used in novel and therapeutic agents and permit faster evaluation of vaccines. However, the growing ethical concerns over animal models and adaptation of alternative methods can be a restraint to the growth of the global in-vivo toxicology market.
Based on the product, the global in-vivo toxicology market is segregated into consumables and instruments. Furthermore, the consumables are segmented into divided into reagents & kits and animal models, including mice models, rat models, and other animal models.
The consumables segment is estimated to the highest growth over the analysis timeframe due to the growth in the development of genetically modified animals, increasing pharmaceutical research for developing new drugs, and rising extensive funding to create new transgenic animal models.
The instruments will grow significantly due to the rising in-vivo toxicology systems adoption, rise in the utilization of in-vivo technology, and rising concerns towards drug safety.
Based on the testing type, the global in-vivo toxicology market is categorized into chronic toxicity testing, sub-chronic toxicity testing, sub-acute toxicity testing, and acute toxicity testing.
The chronic toxicity testing segment is held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to the increasing R&D activities, and rising research focused on drugs used for long-duration therapies, including anti-cancer, anti-hypertensives, anti-arthritis, and anti-convulsive.
The acute toxicity testing segment is poised to witness significant growth over the forecast period. It involves testing for adverse effects arising from single or multiple exposures within a short time frame and highly applicable for animal models.
Based on the toxicity endpoint, the global in-vivo toxicology market is classified into immunotoxicity, systemic toxicity, carcinogenicity, genotoxicity, developmental & reproductive toxicity, and other toxicity endpoints. The immunotoxicity is expected to be the highest revenue share for in-vivo toxicology during the forecast period. The segment’s revenue is primarily attributed to the growing epidemiologic research and increasing demand for biologics and biosimilar development.
The carcinogenicity will witness a lucrative growth rate in the estimated period due to rising studies in animal toxicology, rising prevalence of cancer, and increasing demand for anti-cancer drugs.
The global in-vivo toxicology market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa by geography. North America is estimated to project considerable growth over 2020-2026. It is owing to advents in technology, the presence of leading industry players offering preclinical testing services, and increasing healthcare expenditure.
The Asia Pacific will capture a significant share of the in-vivo toxicology market by 2027. Due to the increasing number of CROs offering in-vivo toxicology services, continually improving healthcare infrastructure in the region, and mounting health care expenditures in emerging countries such as India and China.
Companies such as Danaher, Thermo Fisher Scientific, Charles River, Covance, The Jackson Laboratory, Taconic Biosciences Inc, Eurofins Scientific, Envigoand Dynamic Systems Inc are the key players in the global in-vivo toxicology market.
By Product & Services
By Testing Type
By Toxicity Endpoints
By Region
Global In-vivo Toxicology Market
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